







Never settle for imitations. All impedance/pH probes, recorders and supplies are made to Diversatek Healthcare's exacting specifications.
ZepHr® Impedance/pH Reflux Monitoring System








Never settle for imitations. All impedance/pH probes, recorders and supplies are made to Diversatek Healthcare's exacting specifications.
Selecting the appropriate Reflux Monitoring Test for your patients is more important than ever.
Reflux monitoring, whether pH or impedance/pH, has advantages and drawbacks. The recently updated ACG Practice Guidelines for Diagnosis and Management of GERD provide a simple, yet comprehensive reflux monitoring test selection algorithm1.
What to know about reflux monitoring.
While an empiric PPI trial remains the first-line diagnostic test in suspected GERD patients, nearly 40% of these patients on PPI treatment continue to experience symptoms2.
- A second-line diagnostic test, upper endoscopies are appropriate to determine the extent of esophageal damage. However, over 70% of these are negative3.
- Today’s clinicians have additional diagnostic tools available to help them understand these endoscopy-negative patients with persistent symptoms.
When to choose impedance/pH monitoring?
Patients on PPIs who continue to experience symptoms such as cough, heartburn, regurgitation and chest pain are often difficult to diagnose using traditional pH monitoring. These PPI-refractory, endoscopy-negative patients are optimal candidates for impedance/pH reflux monitoring. In fact, physicians using only acid pH monitoring may miss up to 35% of patients with non-acid reflux.
- The sensitivity of pH-only monitoring in patients with endoscopy-negative reflux symptoms is <71%.
- According to a consensus study by Sifrim et al, when impedance testing is added to pH monitoring, the sensitivity of reflux monitoring approaches 90%4.
ACG Guideline Algorithm

ZepHr Impedance/pH Recorder
- Small size and weight
- Upright and recumbent indicators for easy viewing, easy interface
- SD Card for quick, effortless data download
- Only needs 2 AA batteries and includes a cleanable carrying case
Z/pH Probes
- Enhanced patient comfort
- Optimal ease-of-use
- The widest range of standard configurations to meet your clinical need
- Small diameter for easy insertion
- Made from specially-formulated materials that soften in response to body temperature
- High-quality, single-use
- 100% guaranteed performance
- A variety of esophageal lengths to accommodate any size patient
- Single branch LPR probes with both distal and proximal pH and impedance sensors to identify and characterize acid and nonacid LPR
References
- Philip O. Katz, Lauren B. Gerson and Marcelo F. Vela, Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol advance online publication, February 19, 2013; doi:10.1038/ajg.2012.444.
- Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006;55:1398–1402.
- El-Serag HB. Epidemiology of non-erosive reflux disease. Digestion 2008;78(Suppl 1):6–10.
- Sifrim D, Castell D, Dent J, et al. Gastroesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004;53:1024–31.